.crispr-page { --crispr-gap: 1.25rem; }
.crispr-quick-start { margin: 0 0 1.75rem; color: var(--ink); }
.crispr-quick-start summary { width: fit-content; cursor: pointer; font-weight: 700; padding: .5rem 0; }
.crispr-quick-start summary:focus-visible { outline: 2px solid var(--focus); outline-offset: 3px; }
.crispr-quick-start ol { max-width: 75ch; margin: .5rem 0 0; padding-left: 1.5rem; line-height: 1.6; }
.crispr-quick-start li + li { margin-top: .35rem; }
.crispr-page .sequence-results { scroll-margin-top: var(--crispr-scroll-offset, 110px); }
.crispr-page #crisprResults > .sequence-panel-heading { display: block; }
.crispr-page .sequence-downloads { justify-content: flex-start; flex-direction: row; flex-wrap: wrap; margin-top: .75rem; }
.crispr-page .sequence-downloads .button { flex: none; width: auto; }
.crispr-page fieldset { border: 0; padding: 0; margin: 0; min-width: 0; }
.crispr-options { display: grid; grid-template-columns: minmax(180px, 1fr) minmax(180px, .8fr) minmax(260px, 1.6fr); gap: var(--crispr-gap); align-items: end; }
.crispr-input-options { display: flex; align-items: end; flex-wrap: wrap; gap: var(--crispr-gap); margin: 1rem 0; }
.crispr-input-options .sequence-field { flex: 1 1 240px; }
.crispr-input-options .crispr-nuclease { flex: 1 1 180px; }
.crispr-region-fields { display: grid; grid-template-columns: 2fr 1fr 1fr auto; align-items: end; gap: 1rem; margin: 1rem 0; }
.crispr-target-info { margin: 1rem 0; overflow-wrap: anywhere; }
.crispr-page input, .crispr-page select { min-width: 0; max-width: 100%; }
.crispr-result-tools { margin: 1rem 1.5rem; }
.crispr-page #crisprExpiry { margin: 1rem 1.5rem; }
.crispr-page .sr-only { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0, 0, 0, 0); white-space: nowrap; border: 0; }
.crispr-filters { display: flex; flex-wrap: wrap; align-items: end; gap: 1rem; }
.crispr-filters .sequence-field { flex: 1 1 130px; }
.crispr-selection { display: flex; align-items: center; flex-wrap: wrap; gap: .75rem; margin-top: 1rem; }
.crispr-selection label { display: flex; align-items: center; gap: .5rem; }
.crispr-page input[type="checkbox"] { width: 1.1rem; height: 1.1rem; min-height: 0; margin: .5rem; accent-color: var(--berry); }
.crispr-copy { min-height: 36px; }
.crispr-nuclease { display: flex; flex-direction: column; gap: .55rem; padding-bottom: .65rem; }
.crispr-nuclease > span { font-weight: 700; }
.crispr-hint { color: var(--muted); font-size: var(--text-small); line-height: 1.6; max-width: 100ch; margin: .8rem 0 1.2rem; }
.crispr-page textarea { font-family: var(--font-mono); font-size: .9rem; }
.crispr-page .primer-message[role="status"] { background: var(--surface); color: var(--ink); }
.crispr-page .primer-message[role="alert"] { background: var(--error-soft); color: var(--error); }
.crispr-loading { padding: 1.1rem 1.5rem; border-top: 1px solid var(--border); background: var(--surface); color: var(--ink); }
.crispr-loading-heading { display: flex; align-items: baseline; justify-content: space-between; flex-wrap: wrap; gap: .5rem 1rem; margin-bottom: .8rem; }
#crisprElapsed { font-variant-numeric: tabular-nums; white-space: nowrap; }
.crispr-activity { height: 4px; overflow: hidden; background: var(--border); border-radius: 2px; }
.crispr-activity > span { display: block; width: 30%; height: 100%; background: var(--berry); transform: translateX(-100%); }
.crispr-loading:not([hidden]) .crispr-activity > span { animation: crispr-scan 1.8s cubic-bezier(.25, 1, .5, 1) infinite; }
@keyframes crispr-scan { to { transform: translateX(340%); } }
@media (prefers-reduced-motion: reduce) {
    .crispr-loading:not([hidden]) .crispr-activity > span { animation: none; transform: translateX(116%); }
}
.crispr-table { min-width: 920px; }
.crispr-table td, .crispr-detail td { vertical-align: top; }
.crispr-page code { font-family: var(--font-mono); font-size: .85rem; white-space: nowrap; }
.crispr-table .crispr-pam { color: var(--berry); font-weight: bold; }
.crispr-table th { white-space: nowrap; }
.crispr-guide-link { border: 0; background: none; color: var(--berry); text-decoration: underline; cursor: pointer; padding: .45rem .5rem; font: inherit; min-height: 36px; }
.crispr-table .crispr-flag { display: block; font-size: .875rem; margin-top: .25rem; color: var(--error); }
.crispr-pagination { display: flex; align-items: center; justify-content: flex-end; flex-wrap: wrap; gap: 1rem; margin-top: 1rem; }
.crispr-result-note { padding: .9rem 1rem; background: var(--berry-soft); line-height: 1.6; }
.crispr-detail { border-top: 1px solid var(--border); padding-top: 1.5rem; margin-top: 1.5rem; scroll-margin-top: var(--crispr-scroll-offset, 110px); }
.crispr-detail p { max-width: 90ch; line-height: 1.6; }
.crispr-page button:focus-visible, .crispr-page [tabindex]:focus-visible { outline: 2px solid var(--focus); outline-offset: 3px; }
.crispr-page button:disabled { cursor: not-allowed; opacity: .55; }
.crispr-page [hidden] { display: none !important; }
@media (max-width: 760px) {
    .crispr-options { grid-template-columns: 1fr; gap: .75rem; }
    .crispr-region-fields { grid-template-columns: 1fr; }
    .crispr-page .sequence-panel-heading, .crispr-page .sequence-actions { flex-direction: column; align-items: stretch; gap: .8rem; }
    .crispr-page .sequence-actions > div { display: flex; gap: .5rem; justify-content: flex-end; }
    .crispr-page .sequence-downloads { flex-wrap: wrap; }
    .crispr-pagination { justify-content: space-between; gap: .4rem; }
}